Which structure plays a critical role in memory processing?

The entorhinal gyrus is a key component in memory processing, serving as a critical interface between the neocortex and the hippocampus, which is central to the formation of memories. It is part of the medial temporal lobe and plays a significant role in the encoding and retrieval of declarative memories. The entorhinal gyrus provides crucial inputs to the hippocampus, conveying information about spatial memory and navigation, as well as context for episodic memories. This connectivity underscores its importance in both the integration and organization of memory-related information, making it essential for memory processing.

The involvement of the entorhinal gyrus in memory is further highlighted by its degeneration in conditions such as Alzheimer’s disease, where it is one of the first regions affected, leading to early memory loss in patients. This demonstrates its vital role in the broader memory system.